Septerna, Inc. Common Stock

Septerna, Inc. Common Stock

SEPN · NASDAQ · Healthcare / Biotechnology

42.60USD+0.74 (+1.77%)

Price History

Full chart

Market Stats

Previous Close41.86
Open41.27
Day Range40.60 – 42.88
52-Week Range18.64 – 53.34
Volume333.33K
Market Cap2.44B
P/E (TTM)0.00
Forward P/E107.53
EPS-0.56
Dividend Yield0.00%
Beta2.20
50-Day Avg39.76
200-Day Avg32.69

About

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves' disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women's health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

Company Details

  • SectorHealthcare
  • IndustryBiotechnology
  • CEODr. Jeffrey T. Finer M.D., Ph.D.
  • Employees134
  • Headquarters250 East Grand Avenue, South San Francisco, CA, United States, 94080, USA
  • Websitehttps://www.septerna.com

Leadership

  • Dr. Jeffrey T. Finer M.D., Ph.D.Co-Founder, CEO & Director · b. 1967
  • Ms. Elizabeth P. Bhatt M.B.A., M.S.President & COO · b. 1968
  • Mr. Gilbert M. Labrucherie C.F.A., J.D.Chief Financial Officer · b. 1972
  • Dr. Robert J. Lefkowitz M.D.Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board · b. 1944
  • Dr. Arthur Christopoulos BPHARM, Ph.D.Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board
  • Dr. Patrick Sexton Ph.D.Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board
  • Mr. Richard Hansen Ph.D.Vice President of Technology
  • Mr. Mark A. Wilson J.D.Chief Legal Officer · b. 1972
  • Mr. George Xu Ph.D.Senior Director of Corporate Development & Portfolio Strategy
  • Ms. Samira ShaikhlyChief People Officer · b. 1970

Financials

Income Statement

Currency: USD2022-12-312023-12-312024-12-312025-12-31
Total Revenue0151.00K1.07M45.95M
Growth (%)--+611.92%+4174.51%
Cost of Revenue---1.60M
Gross Profit-151.00K1.07M45.95M
Gross Margin-100.00%100.00%100.00%
Operating Expense--1.92M81.90M126.75M
Operating Income-27.97M2.08M-80.82M-80.80M
Operating Margin-1374.17%-7518.42%-175.83%
EBITDA-27.39M-44.70M-70.89M-47.26M
EBITDA Margin--29603.97%-6594.88%-102.86%
Net Income-27.68M4.18M-71.80M-48.88M
Net Income Margin-2768.21%-6678.88%-106.37%
R&D22.04M35.98M65.34M97.58M
R&D as % of Total Revenue-23827.15%6077.86%212.37%

Balance Sheet

Currency: USD2022-12-312023-12-312024-12-312025-12-31
Total Assets36.12M130.87M456.55M596.19M
Total Liabilities80.32M169.24M36.51M214.26M
Total Equity-44.20M-38.37M420.05M381.93M
Cash30.61M88.48M238.20M120.72M
Total Debt710.00K12.57M25.48M23.63M
Net Debt-29.90M-75.92M-212.72M-97.10M

Cash Flow

Currency: USD2022-12-312023-12-312024-12-312025-12-31
Operating Cash Flow-23.30M-38.72M-67.47M110.19M
Investing Cash Flow-1.29M22.12M-160.60M-229.35M
Financing Cash Flow30.05M74.52M377.78M1.69M
Capital Expenditure1.29M2.88M2.10M518.00K
Free Cash Flow-24.59M-41.60M-69.57M109.67M
FCF to OCF105.53%107.43%103.12%99.53%

Earnings

Report DateAug 28, 2024Nov 20, 2024Mar 27, 2025May 15, 2025Aug 11, 2025Nov 10, 2025Mar 26, 2026May 11, 2026Aug 10, 2026Nov 9, 2026
EPS Estimate0.00-0.94-0.69-0.380.930.79-0.72-0.44-0.48-0.55
EPS Actual-12.76-8.40-0.64-0.49-0.56-0.10-0.24-0.19-0.29-0.57
Surprise--793.62%6.80%-28.95%-160.22%-112.66%66.67%56.82%39.58%-3.64%
Timing-After-hours-After-hoursAfter-hoursPre-market-After-hoursAfter-hoursAfter-hours

Key Statistics & Ratios

Market Cap2.44B
Enterprise Value2.03B
Trailing P/E0.00
Forward P/E107.53
Price / Sales25.38
Price / Book6.12
EPS-0.56
Book Value9.03
Revenue (TTM)96.27M
Gross Profit (TTM)96.27M
EBITDA-71.75M
Profit Margin-61.29%
Operating Margin-144.21%
Return on Equity-14.45%
Return on Assets-7.48%
Shares Outstanding46.68M
Shares Float26.90M
Beta2.20
Dividend Yield0.00%
Dividend Rate0.00
Payout Ratio0.00%

Analyst Ratings

Strong Buy
Based on 10 analystsTarget 59.22
  • Strong Buy
    9
  • Buy
    1

Ownership Breakdown

Institutions
99.35%
Insiders
2.94%
Retail / Other
0.00%

Top Institutional Holders

  • RA Capital Management, LLC
    7.00M14.99%
  • TRV GP V, LLC
    6.22M13.32%
  • Driehaus Capital Management LLC
    4.43M9.50%
  • TRV GP VI, LLC
    4.21M9.02%
  • Samsara BioCapital, LLC
    3.15M6.75%
  • The Goldman Sachs Group Inc
    3.06M6.56%
  • BlackRock Inc
    1.93M4.14%
  • Siren, L.L.C.
    1.90M4.07%
  • venBio Select Advisor LLC
    1.34M2.87%
  • Jupiter Topco LLC
    1.31M2.80%
  • Vanguard Capital Management, LLC
    1.22M2.62%
  • PRIMECAP Management Company
    1.17M2.50%
  • First Light Asset Management, LLC
    963.26K2.06%
  • ADAR1 Capital Management LLC
    940.75K2.02%
  • Geode Capital Management, LLC
    679.16K1.46%
  • State Street Corp
    652.63K1.40%
  • Loomis, Sayles & Company LP
    624.75K1.34%

Top Fund Holders

  • Vanguard MStar Total Stk Mkt Idx Invest
    1.05M2.26%
  • PRIMECAP Odyssey Aggressive Growth
    907.72K1.94%
  • iShares Russell 2000 ETF
    559.15K1.20%