YOLFTbeta
Silence Therapeutics PLC

Silence Therapeutics PLC

SLN · NASDAQ · Healthcare / Biotechnology

19.83USD+0.03 (+0.15%)

Price History

Full chart

Market Stats

Previous Close19.80
Open19.78
Day Range19.76 – 19.86
52-Week Range4.19 – 17.58
Volume586.51K
Market Cap694.88M
P/E (TTM)0.00
Forward P/E0.00
EPS-1.29
Dividend Yield0.00%
Beta1.44
50-Day Avg12.69
200-Day Avg8.07

About

Silence Therapeutics plc, a biotechnology company, engages in the discovery and development of novel molecules incorporating short interfering ribonucleic acid (siRNA) to inhibit the expression of specific target genes in hematology, cardiovascular, and rare diseases. The company develops Divesiran (SLN124), which is in Phase 2 development for polycythemia vera, and SLN548 for complement-mediated renal diseases. It also develops Zerlasiran (SLN360) for cardiovascular disease associated with elevated lipoprotein(a); SLN312 for dyslipidemia; SLN365 for hypercholesterolemia; and SLN098 for obesity. The company was formerly known as SR Pharma plc and changed its name to Silence Therapeutics plc in May 2007. Silence Therapeutics plc was incorporated in 1994 and is headquartered in London, United Kingdom.

Company Details

  • SectorHealthcare
  • IndustryBiotechnology
  • CEOMr. Iain Gladstone Ross B.Sc., BSc (Hons), C.DIR, CH.D
  • Employees88
  • Headquarters12 Hammersmith Grove, London, United Kingdom, W6 7AP, USA
  • Websitehttps://www.silence-therapeutics.com

Leadership

  • Mr. Iain Gladstone Ross B.Sc., BSc (Hons), C.DIR, CH.DInterim CEO & Chairman of the Board · b. 1954
  • Ms. Rhonda L. HellumsExecutive VP, CFO, Secretary & Executive Director · b. 1971
  • Dr. Steven J. Romano M.D.Executive VP and Chief Research & Development Officer · b. 1959
  • Dr. Marie Wikstrom Lindholm Ph.D.Chief Scientific Officer
  • Ms. Gem Gokmen HopkinsHead of IR & Corporate Communications
  • Mr. Jaimin B. ShahSVP & General Counsel
  • Mr. J.P. GabrielChief Technical Operations Officer
  • Mr. Curtis Rambaran M.D.Chief Medical Officer

Financials

Income Statement

Currency: USD1995-12-311996-12-311997-12-311998-12-311999-12-312000-12-312001-12-312002-12-312003-12-312004-12-312005-12-312006-12-312007-12-312008-12-312009-12-312010-12-312011-12-312012-12-312013-12-312014-12-312015-12-312016-12-312017-12-312018-12-312019-12-312020-12-312021-12-312022-12-312023-12-312024-12-312025-12-31
Total Revenue---210.00K1.37M959.00K138.00K1.15M1.34M159.00K509.00K1.95M4.05M2.21M1.72M2.37M720.13K163.00K117.00K15.00K-770.00K16.00K0244.00K5.48M12.41M17.65M25.38M43.26M559.00K
Growth (%)----+552.38%-30.00%-85.61%+734.06%+16.77%-88.17%+220.13%+282.51%+107.86%-45.42%-22.00%+37.32%-69.56%-77.37%-28.22%-87.18%---97.92%-100.00%-+2145.49%+126.59%+42.19%+43.74%+70.47%-98.71%
Cost of Revenue------------4.84M6.71M5.07M5.82M3.36M3.38M5.65M8.88M7.11M8.71M7.94M9.74M-3.76M7.46M10.97M10.32M11.81M215.00K
Gross Profit---210.00K1.37M959.00K138.00K1.15M1.34M-1.47M509.00K1.95M-796.00K-4.50M-3.35M-3.46M-2.67M-3.21M-5.53M-8.87M-7.11M-7.94M-7.93M-9.74M244.00K1.72M4.96M6.68M15.06M31.45M344.00K
Gross Margin---100.00%100.00%100.00%100.00%100.00%100.00%-923.72%100.00%100.00%-19.67%-203.85%-194.43%-146.03%-370.35%-1972.39%-4727.35%-59126.67%--1031.30%-49543.75%-100.00%31.34%39.94%37.83%59.34%72.70%61.54%
Operating Expense---2.11M3.55M3.69M3.17M3.16M4.02M1.90M4.41M6.21M4.99M3.29M4.20M5.20M3.12M2.61M3.54M3.26M2.65M3.96M6.46M10.83M22.98M37.56M50.77M56.44M64.66M94.77M90.10M
Operating Income-933.00K-1.24M-2.16M-1.90M-2.18M-2.73M-3.03M-2.00M-2.67M-3.37M-3.90M-4.27M-5.79M-7.79M-7.55M-8.66M-5.79M-5.83M-9.07M-12.13M-9.77M-11.91M-14.39M-20.57M-22.73M-35.85M-45.81M-49.76M-49.60M-63.32M-89.75M
Operating Margin----906.19%-159.05%-285.19%-2193.48%-174.20%-198.88%-2118.24%-765.82%-219.21%-143.02%-352.74%-438.42%-365.93%-803.46%-3575.46%-7753.85%-80846.67%--1546.23%-89943.75%--9317.21%-654.26%-369.02%-281.87%-195.48%-146.38%-16055.99%
EBITDA-932.00K-1.21M-2.13M-1.87M-2.17M-2.71M-2.98M-1.95M-2.63M-3.20M-3.42M-3.59M-5.32M-7.44M-7.01M-8.41M-5.42M-5.31M-8.78M-11.79M-9.59M-11.60M-3.33M-20.17M-22.36M-35.53M-45.42M-39.94M-49.78M-48.99M-88.05M
EBITDA Margin----889.05%-158.61%-282.17%-2163.04%-169.33%-195.61%-2011.32%-671.51%-184.18%-131.36%-336.85%-406.95%-355.41%-752.50%-3255.83%-7500.00%-78633.33%--1505.97%-20793.75%--9161.89%-648.46%-365.86%-226.24%-196.17%-113.25%-15750.63%
Net Income-874.00K-965.00K-1.76M-1.58M-2.14M-1.94M-2.19M-1.48M-2.28M-2.96M-3.58M-3.83M-5.11M-7.43M-7.47M-8.79M-5.74M-26.28M-9.00M-11.09M-6.64M-8.44M-1.62M-18.41M-19.58M-32.55M-39.41M-41.03M-43.27M-45.31M-88.61M
Net Income Margin----751.90%-156.20%-202.71%-1589.86%-128.84%-169.64%-1859.12%-704.32%-196.51%-126.22%-336.58%-433.60%-371.72%-796.66%-16125.15%-7694.02%-73920.00%--1096.10%-10112.50%--8025.41%-594.03%-317.44%-232.44%-170.51%-104.74%-15851.88%
R&D790.00K986.00K1.83M1.68M3.05M3.00M2.49M2.46M3.01M1.70M1.66M3.19M4.84M6.71M5.07M5.82M3.36M3.38M5.65M8.88M7.11M8.71M7.94M9.74M13.34M20.21M30.77M35.50M44.02M67.88M67.75M
R&D as % of Total Revenue---801.90%222.34%312.93%1805.80%213.38%224.11%1067.30%325.93%163.64%119.67%303.85%294.43%246.07%466.58%2072.39%4827.35%59226.67%-1131.30%49643.75%-5465.57%368.84%247.81%201.11%173.50%156.93%12120.39%
Interest Expense59.00K279.00K398.00K324.00K163.00K505.00K479.00K302.00K216.00K71.00K1.00K1.00K544.00K31.00K46.00K63.00K13.00K30.00K70.00K147.00K340.00K1.54M15.00K45.00K33.00K16.00K8.00K47.00K34.00K--
Interest Expense % of Total Revenue---154.29%11.90%52.66%347.10%26.24%16.07%44.65%0.20%0.05%13.44%1.40%2.67%2.66%1.81%18.40%59.83%980.00%-200.52%93.75%-13.52%0.29%0.06%0.27%0.13%--

Balance Sheet

Currency: USD1995-12-311996-12-311997-12-311998-12-311999-12-312000-12-312001-12-312002-12-312003-12-312004-12-312005-12-312006-12-312007-12-312008-12-312009-12-312010-12-312011-12-312012-12-312013-12-312014-12-312015-12-312016-12-312017-12-312018-12-312019-12-312020-12-312021-12-312022-12-312023-12-312024-12-312025-12-31
Total Assets3.06M6.81M5.27M3.95M10.81M12.10M9.67M8.49M6.49M3.19M17.17M16.75M19.48M14.38M10.99M33.96M33.44M17.07M29.30M29.77M61.55M55.79M55.01M38.88M46.08M85.97M96.19M107.50M94.53M161.85M131.44M
Total Liabilities301.00K417.00K640.00K603.00K1.60M964.00K725.00K1.03M1.31M846.00K1.49M1.04M1.80M935.00K2.10M1.69M1.26M959.00K1.72M2.01M1.12M1.61M2.66M3.83M25.17M76.91M87.67M85.43M77.12M54.80M69.14M
Total Equity2.76M6.39M4.63M3.34M9.21M11.14M8.95M7.46M5.18M2.34M15.69M15.71M17.68M13.44M8.89M32.27M32.18M16.12M27.58M27.76M60.43M54.18M52.35M35.05M20.91M9.06M8.53M22.07M21.99M107.05M62.30M
Cash1.25M6.70M5.18M3.66M10.53M11.43M9.08M7.16M5.09M2.63M9.09M8.82M10.17M3.35M1.13M3.57M3.69M8.91M15.89M16.86M51.91M39.01M42.74M21.49M13.52M27.45M73.54M54.82M54.44M96.91M11.28M
Total Debt------------------------287.00K341.00K137.00K446.00K273.81K93.45K160.00K
Net Debt-1.25M-6.70M-5.18M-3.66M-10.53M-11.43M-9.08M-7.16M-5.09M-2.63M-9.09M-8.82M-10.17M-3.35M-1.13M-3.57M-3.69M-8.91M-15.89M-16.86M-51.91M-39.01M-42.74M-21.49M-13.23M-27.11M-73.40M-54.37M-54.16M-96.82M-11.12M

Cash Flow

Currency: USD1995-12-311996-12-311997-12-311998-12-311999-12-312000-12-312001-12-312002-12-312003-12-312004-12-312005-12-312006-12-312007-12-312008-12-312009-12-312010-12-312011-12-312012-12-312013-12-312014-12-312015-12-312016-12-312017-12-312018-12-312019-12-312020-12-312021-12-312022-12-312023-12-312024-12-312025-12-31
Operating Cash Flow-761.00K-727.00K-1.52M-1.81M-1.13M-2.86M-2.28M-1.84M-2.04M-2.48M-2.78M-4.03M-3.83M-6.98M-4.65M-10.55M-5.11M-4.88M-6.76M-9.46M-8.26M-10.07M-9.60M-16.76M1.73M-10.78M9.19M-57.04M-39.35M-54.05M-62.27M
Investing Cash Flow384.00K-97.00K-7.00K1.47M-6.19M-926.00K1.51M7.94M-43.00K15.00K-212.00K218.00K12.00K13.00K-179.00K559.00K-244.00K-133.00K-5.10M-201.00K4.33M-4.67M13.01M-4.83M-15.02M9.62M11.71M-20.50M16.43M-17.55M-47.99M
Financing Cash Flow1.63M6.27M6.00K289.00K8.00M3.87M---5.00K9.45M3.54M5.17M4.00K2.67M12.42M5.52M10.25M18.78M10.84M39.15M-101.00K48.00K341.00K5.27M15.43M41.45M52.58M25.16M113.54M15.00K
Capital Expenditure2.00K97.00K7.00K5.00K4.00K116.00K6.00K74.00K31.00K19.00K84.00K129.00K531.00K272.00K225.00K292.00K275.00K202.00K138.00K338.00K850.00K537.00K173.00K188.00K9.00K514.00K1.80M545.00K45.00K168.61K55.00K
Free Cash Flow-763.00K-824.00K-1.53M-1.81M-1.14M-2.98M-2.29M-1.92M-2.07M-2.50M-2.87M-4.16M-4.36M-7.25M-4.87M-10.84M-5.38M-5.08M-6.89M-9.80M-9.11M-10.60M-9.77M-16.95M1.72M-11.29M7.39M-57.59M-39.40M-54.22M-62.33M
FCF to OCF100.26%113.34%100.46%100.28%100.35%104.06%100.26%104.02%101.52%100.77%103.02%103.20%113.85%103.90%104.84%102.77%105.38%104.14%102.04%103.57%110.30%105.33%101.80%101.12%99.48%104.77%80.40%100.96%100.11%100.31%100.09%

Earnings

Report DateDec 31, 2010Mar 31, 2011Jun 30, 2011Sep 30, 2011Dec 31, 2011Mar 31, 2012Jun 30, 2012Sep 30, 2012Dec 31, 2012Mar 31, 2013Jun 30, 2013Sep 30, 2013Dec 31, 2013Mar 31, 2014Jun 30, 2014Sep 30, 2014Dec 31, 2014Mar 31, 2015Jun 30, 2015Sep 30, 2015Dec 31, 2015Mar 31, 2016Jun 30, 2016Sep 30, 2016Dec 31, 2016Mar 31, 2017Jun 30, 2017Sep 30, 2017Dec 31, 2017Mar 31, 2018Jun 30, 2018Sep 30, 2018Dec 31, 2018Mar 31, 2019Jun 30, 2019Sep 30, 2019Dec 31, 2019Mar 31, 2020Jun 30, 2020Sep 30, 2020Dec 31, 2020Mar 31, 2021Jun 2, 2021Aug 12, 2021Nov 16, 2021Mar 17, 2022May 16, 2022Sep 14, 2022Nov 10, 2022Mar 15, 2023May 16, 2023Aug 16, 2023Nov 14, 2023Mar 13, 2024May 14, 2024Aug 15, 2024Nov 14, 2024Feb 27, 2025May 8, 2025Aug 7, 2025Nov 6, 2025Mar 5, 2026May 20, 2026Aug 10, 2026Nov 5, 2026
EPS Estimate0.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.00-0.550.85-0.15-0.14-0.19-0.20-0.20-0.01-0.15-0.67-0.38-0.21-0.11-0.11-0.13-0.25-0.41-0.27-0.21-0.49-0.23-0.32-0.26
EPS Actual-0.24-0.39-0.39-0.16-0.15-1.63-1.60-0.08-0.08-0.06-0.06-0.10-0.10-0.10-0.10-0.09-0.08-0.05-0.06-0.03-0.03-0.05-0.05-0.03-0.03-0.05-0.050.040.04-0.09-0.08-0.09-0.09-0.08-0.07-0.09-0.10-0.09-0.08-0.14-0.18-0.16-0.55-0.31-0.15-0.14-0.11-0.15-0.080.45-0.12-0.37-0.27-0.48-0.05-0.43-0.730.17-0.60-0.54-0.15-0.27-0.33-0.26-
Surprise------------------------------------------0.00%-136.91%1.97%-0.42%44.76%22.59%58.18%3748.39%21.28%44.78%28.95%-128.57%52.71%-290.91%-461.54%169.33%-46.34%-100.00%28.57%44.90%-44.36%18.75%-
Timing--------------------------------------------Pre-market------Pre-marketPre-marketPre-market-Pre-marketPre-market-Pre-marketPre-marketPre-marketPre-market-Pre-marketPre-market

Key Statistics & Ratios

Market Cap694.88M
Enterprise Value673.91M
Trailing P/E0.00
Forward P/E0.00
Price / Sales1129.89
Price / Book18.60
EPS-1.29
Book Value0.814
Revenue (TTM)615.00K
Gross Profit (TTM)528.00K
EBITDA-63.94M
Profit Margin0.00%
Operating Margin-10475.61%
Return on Equity-90.41%
Return on Assets-29.65%
Shares Outstanding62.15M
Shares Float37.84M
Beta1.44
Dividend Yield0.00%
Dividend Rate0.00
Payout Ratio0.00%

Analyst Ratings

Buy
Based on 7 analystsTarget 33.00
  • Strong Buy
    3
  • Buy
    3
  • Sell
    1

Ownership Breakdown

Institutions
39.68%
Insiders
7.97%
Retail / Other
52.35%

Top Institutional Holders

  • TCG Crossover Management, LLC
    3.03M4.88%
  • Siren, L.L.C.
    2.91M4.68%
  • Redmile Group, LLC
    2.16M3.48%
  • Nantahala Capital Management, LLC
    2.15M3.45%
  • Citadel Advisors Llc
    1.33M2.14%
  • Nextech Invest, Ltd.
    952.40K1.53%
  • Millennium Management LLC
    909.28K1.46%
  • Ikarian Capital, LLC
    865.78K1.39%
  • Polygon Management Ltd
    764.26K1.23%
  • Soleus Capital Management, L.P.
    630.00K1.01%
  • 5AM Venture Management, LLC
    476.20K0.77%
  • Great Point Partners LLC
    450.00K0.72%
  • SG Americas Securities, LLC
    286.70K0.46%
  • UBS Group AG
    246.94K0.40%
  • BOOTHBAY FUND MANAGEMENT, LLC
    209.09K0.34%

Top Fund Holders

  • International Biotechnology Ord
    729.62K1.17%
  • MEDICAL BioHealth EUR Acc
    543.63K0.87%
  • Fidelity Advisor Biotechnology I
    482.09K0.78%
  • apo Medical Opportunities R
    245.19K0.39%
  • iShares Biotechnology ETF
    234.01K0.38%